My answer is that almost everyooe over age 25 has DHEA deficiency, and that restoring DHEA availability is a good (best) idea, regardless of diagnosis.
Basically, a tumour cell has to shut off the TP53 gene, in order to avoid apoptosis - then, it prevents the formation of lethal ROS production, via the action of G6PD. DHEA blocks G6PD, allowing ROS production: so the cell dies.
But we all reduce DHEA production by 1%/year, from age 25! Furthermore, those who grew up in a high-stress family setting mostly have DHEA suppression and are already DHEA deficient before age 20.
SO: supplement everyone, except women with PCO (they overproduce DHEA, as part of the syndrome).
Beautiful, and important!
Does DHEA, which ensures activation of TP53 by blocking 6GPD, fit in, with this ?
Hi, thank you for your question. It's a good one. Sorry, I don't know the answer to that one.
My answer is that almost everyooe over age 25 has DHEA deficiency, and that restoring DHEA availability is a good (best) idea, regardless of diagnosis.
However, see the original paper, by JW Nyce, at https://www.preprints.org/manuscript/202304.0253, and my post, "DHEA prevents cancer", at
https://gervaisharry.substack.com/p/dhea-prevents-cancer......... Or just read my post (!)
Basically, a tumour cell has to shut off the TP53 gene, in order to avoid apoptosis - then, it prevents the formation of lethal ROS production, via the action of G6PD. DHEA blocks G6PD, allowing ROS production: so the cell dies.
But we all reduce DHEA production by 1%/year, from age 25! Furthermore, those who grew up in a high-stress family setting mostly have DHEA suppression and are already DHEA deficient before age 20.
SO: supplement everyone, except women with PCO (they overproduce DHEA, as part of the syndrome).
Thanks for your valuable input. I am going to take a deep look into it all over the weekend. Excellent material!