Prostate Cancer and Fenbendazole

Plus other benzimidazole drugs.

Sources grouped according to the primary repurposed drug or therapeutic compound.

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1. Fenbendazole (Monotherapy, Nanotechnology & Formulation Studies)

• β-Lactoglobulin-Modified Mesoporous Silica Nanoparticles (MCM-48) for Targeted Delivery of Fenbendazole into Prostate Cancer Cells
  Publication: Pharmaceutics

• PEGylated Mesoporous Silica Nanoparticles (MCM-41): A Promising Carrier for Targeted Delivery of Fenbendazole into Prostate Cancer Cells
  Publication: Pharmaceutics

• Physicochemical, Pharmacokinetic, and Toxicity Evaluation of Soluplus® Polymeric Micelles Encapsulating Fenbendazole
  Publication: Pharmaceutics

• Investigation of Fenbendazole Solubility Using Particle Size Reduction Methods in the Presence of Soluplus®
  Publication: Pharmaceutics

• Evaluation of Drug–Polymer Compatibility and Dissolution Behaviour of Fenbendazole–Soluplus® Solid Dispersions Prepared by Hot-Melt Extrusion
  Publication: Polymers

• Anti-Cancer Effect of Fenbendazole-Incorporated PLGA Nanoparticles in Ovarian Cancer
  Publication: Journal of Gynecologic Oncology

• Evaluation of Chemical Composition, Dissolution, and Cytotoxicity of Commercial Fenbendazole Formulations
  Publication: Journal of Pharmaceutical and Biomedical Analysis / Current Research

• Fenbendazole Exhibits Differential Anticancer Effects In Vitro and In Vivo in Models of Mouse Lymphoma
  Publication: Current Issues in Molecular Biology

• Differential Cytotoxic Effects of Fenbendazole on Mouse Lymphoma Cells and Normal Spleen Cells
  Publication: Korean Journal of Veterinary Research

• Involvement of Reactive Oxygen Species in the Anti-Cancer Activity of Fenbendazole
  Publication: Korean Journal of Veterinary Research

• Anti-Cancer Effects of Fenbendazole on 5-Fluorouracil-Resistant Colorectal Cancer Cells
  Publication: The Korean Journal of Physiology & Pharmacology

• Transcriptome Analysis Reveals the Anticancer Effects of Fenbendazole on Ovarian Cancer
  Publication: BMC Cancer

• Exceptional Repositioning of Dog Dewormer: Fenbendazole Fever and Clinical Self-Administration Risks
  Publication: Current Issues in Molecular Biology

2. Fenbendazole Synergistic Combination Therapies

• Synergistic Anti-Tumor Effect of Fenbendazole and Diisopropylamine Dichloroacetate in Non-Small Cell Lung Cancer
  Publication: Translational Lung Cancer Research

3. Ivermectin & Fenbendazole Co-Use (Observational Cohorts & Alternative Media)

• Patterns of Ivermectin and Fenbendazole Use Among Patients with Cancers: A Single-Institutional Experience
  Publication: UT MD Anderson Cancer Center Retrospective Study

• Makis Health: Digital Newsletter on Repurposed Medications and Alternative Oncology
  Publication: Substack Educational Platform & Case Commentary

4. Mebendazole (Monotherapy & Combinations)

• Repurposing Mebendazole as a Novel Anti-Cancer Therapeutic
  Publication: ecancermedicalscience

• Evaluation of Mebendazole and Flutamide Dual Therapy in Human Prostate Cancer Cell Lines
  Publication: Preclinical Synergistic Oncology Research

• Real-World Clinical Outcomes and Safety of Compounded Ivermectin and Mebendazole in Cancer Care
  Publication: Prospective Observational Cohort Study

5. Albendazole & Benzimidazole Screens

• Repurposing of Albendazole as a Novel Treatment for Prostate Cancer via ROS Elevation and Wnt/β-Catenin Downregulation
  Publication: Oncology Letters

• Phenotype-Based Drug Screen Identifies Repurposed Anthelmintics Against Aggressive Metastatic Prostate Cancer
  Publication: Frontiers in Oncology (Evaluates both Fenbendazole and Albendazole)

6. Flubendazole

• Flubendazole as a Promising Anti-Tumor Medication: Mechanisms and Multi-Cancer Applications
  Publication: International Journal of Molecular Sciences

• Therapeutic Repurposing of Flubendazole for Hepatocellular Carcinoma via PCSK9 Targeting
  Publication: Journal of Hepatocellular Carcinoma

7. Chemoinformatics & General Molecular Mechanisms (Prostate Focus)

• In Silico Computationally Driven Drug Repurposing Workflow for Advanced Prostate Cancer
  Publication: International Journal of Molecular Sciences

• Ferroptosis in Prostate Cancer: Mechanisms and Novel Therapeutic Strategies
  Publication: Prostate Cancer and Prostatic Diseases