Cancer and Glucose
What you need to know
Cancer cells rely on glucose as their main fuel. They absorb it faster than normal cells, so reducing glucose may slow their growth and help eliminate them. I believe, based on the science, this is how fenbendazole works.
Monitoring is crucial, with regular assessments of blood levels for vitamins and minerals to ensure safety and efficacy.
A Keto diet may be worth considering.
Inhibition of Glucose Uptake in Cancer Cells
Malignant cells exhibit elevated glucose uptake, consuming glucose at up to 200 times the rate of normal cells via aerobic glycolysis (the Warburg effect). This phenomenon is detected on PET scans, where regions with greater glucose uptake often correspond to cancerous tumors or inflammatory sites.
Fenbendazole limits cancer cell fueling in several ways:
It decreases the expression of glucose transporter proteins (GLUTs), which mediate glucose entry into cancer cells from the bloodstream.
Additionally, it inhibits hexokinase 2, an enzyme essential for cancer cell survival. This enzyme contributes to tumor proliferation by facilitating glycolytic flux and promoting lactic acid production in the tumor microenvironment.
How does Fenbendazole work?
*https://www.fenbendazole.org/fenbendazole-information/how-fenbendazole-works/
In our earlier work, we reported a potent growth-inhibitory activity of FZ[fenbendazole] caused partially by impairment of proteasomal function. Here, we show that FZ demonstrates moderate affinity for mammalian tubulin and exerts cytotoxicity to human cancer cells at micromolar concentrations. Simultaneously, it caused mitochondrial translocation of p53 and effectively inhibited glucose uptake, expression of GLUT transporters as well as hexokinase (HK II) - a key glycolytic enzyme that most cancer cells thrive on. It blocked the growth of human xenografts in nu/nu mice model when mice were fed with the drug orally. The results, in conjunction with our earlier data, suggest that FZ is a new microtubule interfering agent that displays anti-neoplastic activity and may be evaluated as a potential therapeutic agent because of its effect on multiple cellular pathways leading to effective elimination of cancer cells.
Dogra, N., Kumar, A. & Mukhopadhyay, T. (2018). Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways. Scientific Reports. https://doi.org/10.1038/s41598-018-30158-6
….inhibiting tumors and targeting drug-resistant cancer cells through glycolysis inhibition.
Glucose, a primary energy source for tumor cells. Fenbendazole has been found to inhibit glucose uptake. Fenbendazole exhibits several other mechanisms contributing to its anti-cancer effects, primarily by disrupting energy metabolism.
Nguyen J, Nguyen TQ, Han BO, Hoang BX. Oral Fenbendazole for Cancer Therapy in Humans and Animals. Anticancer Res. 2024;44(9):3725-3735. doi:10.21873/anticanres.17197